Details

Autor(en) / Beteiligte

• Guthmiller, Jenna J
• Wilson, Patrick C

Titel

Remembering seasonal coronaviruses

Ist Teil von

• Science (American Association for the Advancement of Science), 2020-12, Vol.370 (6522), p.1272-1273

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Antibodies against seasonal coronaviruses react with SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has differential effects according to age, with symptomatic and severe infections mostly occurring in older adults. One possible explanation for this variation is that children and younger adults have more preexisting immunity against seasonal human coronaviruses (HCoVs) that cross-react with SARS-CoV-2, providing protection from severe and even symptomatic SARS-CoV-2 infection. Consistently, SARS-CoV-2 cross-reactive memory CD4 + and CD8 + T cells against the spike protein, the major surface protein of coronaviruses, have been reported in unexposed individuals ( 1 , 2 ). Whether humoral immunity (antibodies and memory B cells) against SARS-CoV-2 cross-reacts with seasonal HCoVs is now emerging. On page 1339 of this issue, Ng et al. ( 3 ) and Shrock et al. ( 4 ) reveal that individuals exposed and unexposed to SARS-CoV-2 have cross-reactive serum antibodies against the spike protein of SARS-CoV-2 and seasonal HCoVs.