Details

Autor(en) / Beteiligte

• Guglielmelli, Alexa
• Rosa, Paolo
• Contardi, Marco
• Prato, Mirko
• Mangino, Giorgio
• Miglietta, Selenia
• Petrozza, Vincenzo
• Pani, Roberto
• Calogero, Antonella
• Athanassiou, Athanassia
• Perotto, Giovanni
• De Sio, Luciano

Titel

Biomimetic keratin gold nanoparticle-mediated in vitro photothermal therapy on glioblastoma multiforme

Ist Teil von

• Nanomedicine (London, England), 2021-01, Vol.16 (2), p.121-138

Ort / Verlag

England: Future Medicine Ltd

Erscheinungsjahr

2021

Beschreibungen/Notizen

• To realize and characterize a new generation of keratin-coated gold nanoparticles (Ker-AuNPs) as highly efficient photosensitive nanosized therapeutics for plasmonic photothermal (PPT) therapy. The chemical, physical, morphological and photothermal properties of Ker-AuNPs are investigated using dynamic light scattering, ζ-potential, UV-Visible, Fourier transform infrared spectroscopy, x-ray photoelectron spectroscopy, transmission electron microscopy and high-resolution thermography. experiments are performed on a human glioblastoma cell line (i.e., U87-MG), using viability assays, transmission electron microscopy, fluorescence microscopy, cytometric analyses and PPT experiments. Experiments confirm the excellent biocompatibility of Ker-AuNPs, their efficient cellular uptake and localized photothermal heating capabilities. The reported structural and functional properties pointed out these Ker-AuNPs as a promising new tool in the field of biocompatible photothermal agents for PPT treatments against cancer-related diseases.