Details

Autor(en) / Beteiligte

• Kawamura, Kazunori
• Kumata, Katsushi
• Mori, Wakana
• Fujinaga, Masayuki
• Kurihara, Yusuke
• Ogawa, Masanao
• Ohkubo, Takayuki
• Furutsuka, Kenji
• Hashimoto, Hiroki
• Nengaki, Nobuki
• Zhang, Ming-Rong

Titel

Radiosynthesis of 18F-fluoroethylated tracers via a simplified one-pot 18F-fluoroethylation method using [18F]fluoroethyl tosylate

Ist Teil von

• Applied radiation and isotopes, 2021-03, Vol.169, p.109571-109571, Article 109571

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2021

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Recently, a straightforward one-pot method for 18F-fluoroethylation without azeotropic drying of cyclotron-produced [18F]F− was developed. In this study, we have attempted to simplify the automated radiosynthesis of two [18F]fluoroethylated tracers, [18F]FEDAC and [18F]FET, using a desmethyl labeling precursor and [18F]fluoroethyl tosylate, based on the above-mentioned method. The radiochemical yields of [18F]FEDAC and [18F]FET were 26 ± 3.7% (n = 5) and 14 ± 2.2% (n = 4), respectively, based on total [18F]F− at the end of irradiation. •The simplified one-pot 18F-fluoroethylation method has developed.•The radiosynthesis of [18F]FEDAC and [18F]FET were simplified.•A lower cost of the precursors for 18F-fluoroethylation is provided.•A shorter synthesis time for 18F-fluoroethylation is provided.•Automated one-pot 18F-fluoroethylation strategy is provided.