Trends in Cancer, 2021-03, Vol.7 (3), p.181-185
2021
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- Autor(en) / Beteiligte
- Titel
- Assessing Novel Therapies Based on Late-Stage Efficacy: A Dangerous Concept?
- Ist Teil von
- Trends in Cancer, 2021-03, Vol.7 (3), p.181-185
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Traditionally, the efficacy of novel cancer therapies has been confirmed in patients failing regular treatment before being tested in early disease. Improved understanding of the mechanisms guiding therapeutic efficacy may challenge this dogma, suggesting novel therapies to move into early evaluation based on biological rationales without late-stage efficacy evaluation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2405-8033eISSN: 2405-8025DOI: 10.1016/j.trecan.2020.11.010Titel-ID: cdi_proquest_miscellaneous_2473417568
- Format
- –
- Schlagworte
- Antineoplastic Combined Chemotherapy Protocols - administration & dosage, Antineoplastic Combined Chemotherapy Protocols - adverse effects, Clinical Trials as Topic - ethics, Clinical Trials as Topic - standards, Drug Resistance, Neoplasm - drug effects, Drugs, Investigational - administration & dosage, Drugs, Investigational - adverse effects, Humans, Neoplasm Staging, Neoplasms - diagnosis, Neoplasms - drug therapy, Neoplasms - mortality, Neoplasms - pathology, Patient Selection - ethics, Time Factors, Treatment Outcome