Details

Autor(en) / Beteiligte

• González-Castro, Thelma B
• Tovilla-Zárate, Carlos A
• López-Narvaez, María L
• Juárez-Rojop, Isela E
• Calderón-Colmenero, Juan
• Sandoval, Juan P
• García-Montes, José A
• Blachman-Braun, Ruben
• Castillo-Avila, Rosa G
• García-Flores, Esbeidy
• Cazarín-Santos, Benny G
• Borgonio-Cuadra, Verónica M
• Posadas-Sánchez, Rosalinda
• Vargas-Alarcón, Gilberto
• Rodríguez-Pérez, José M
• Pérez-Hernández, Nonanzit

Titel

Association between congenital heart disease and NKX2.5 gene polymorphisms: systematic review and meta-analysis

Ist Teil von

• Biomarkers in medicine, 2020-12, Vol.14 (18), p.1747-1757

Ort / Verlag

England: Future Medicine Ltd

Erscheinungsjahr

2020

Beschreibungen/Notizen

• To analyze the association of gene with congenital heart disease (CHD), and to determine if the variants rs703752, rs3729753 and rs2277923 increase the risk for developing CHD. PubMed, EBSCO and Web of Science databases were screened to identify eligible studies. Through a comprehensive meta-analysis software, the association between gene variants and susceptibility of CHD was calculated by pooled odd ratio (ORs) and 95% CI. We observed that the allelic model of rs703752 and rs2277923 increased the risk in the overall population: OR = 1.24; 95% CI: 1.00-1.55; Z p-value = 0.049; OR = 1.18; 95% CI: 0.01-1.37; Z p-value = 0.036; respectively. Our results suggested that the rs703752 and rs2277923 polymorphisms of the gene are associated with CHD.