Details

Autor(en) / Beteiligte

• Wei, Tong
• Chen, Xiao-Juan
• Zhang, Lu-Yang
• Zhang, Ao-Li
• Zhu, Xiao-Fan

Titel

Clinical significance of minimal residual disease in B-lineage acute lymphoblastic leukemia pediatric patients with different fusion gene backgrounds

Ist Teil von

• Zhongguo dang dai er ke za zhi, 2020-12, Vol.22 (12), p.1279

Ort / Verlag

China

Erscheinungsjahr

2020

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• To study the clinical significance of minimal residual disease (MRD) in B-lineage acute lymphoblastic leukemia (B-ALL) pediatric patients with different fusion gene backgrounds. A retrospective analysis was performed on the medical data of 441 B-ALL children who were treated from January 2008 to April 2015. Among the 441 children, 336 had negative fusion gene, 79 had positive fusion gene, and 26 had positive fusion gene. Flow cytometry was used to detect MRD, and the influence of MRD on day 15 (TP1), day 33 (TP2), and week 12 (TP3) of induction therapy on prognosis was analyzed. In patients with negative fusion gene, the positive MRD group had significantly lower overall survival (OS) rate and event-free survival (EFS) rate ( < 0.05) and significantly higher recurrence rate and mortality rate at TP1, TP2, and TP3, compared with the negative MRD group ( < 0.05). In patients with positive , the positive MRD group had significantly lower OS and EFS rates ( < 0.05) and significantly higher recurrence rate and mor