Details

Autor(en) / Beteiligte

• McAlister, Emma
• Dutton, Bridie
• Vora, Lalitkumar K.
• Zhao, Li
• Ripolin, Anastasia
• Zahari, Dk Siti Zawanah Binti Pg Hj
• Quinn, Helen L.
• Tekko, Ismaiel A.
• Courtenay, Aaron J.
• Kelly, Stephen A.
• Rodgers, Aoife M.
• Steiner, Lilach
• Levin, Galit
• Levy‐Nissenbaum, Etgar
• Shterman, Nava
• McCarthy, Helen O.
• Donnelly, Ryan F.

Titel

Directly Compressed Tablets: A Novel Drug‐Containing Reservoir Combined with Hydrogel‐Forming Microneedle Arrays for Transdermal Drug Delivery

Ist Teil von

• Advanced healthcare materials, 2021-02, Vol.10 (3), p.e2001256-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Microneedle (MN) patches consist of a hydrogel‐forming MN array and a drug‐containing reservoir. Drug‐containing reservoirs documented in the literature include polymeric films and lyophilized wafers. While effective, both reservoir formulations are aqueous based, and so degradation can occur during formulation and drying for drugs inherently unstable in aqueous media. The preparation and characterization of novel, nonaqueous‐based, directly compressed tablets (DCTs) for use in combination with hydrogel‐forming MN arrays are described for the first time. In this work, a range of drug molecules are investigated. Precipitation of amoxicillin (AMX) and primaquine (PQ) in conventional hydrogel‐forming MN arrays leads to use of poly(vinyl alcohol)‐based MN arrays. Following in vitro permeation studies, in vivo pharmacokinetic studies are conducted in rats with MN patches containing AMX, levodopa/carbidopa (LD/CD), and levofloxacin (LVX). Therapeutically relevant concentrations of AMX (≥2 µg mL−1), LD (≥0.5 µg mL−1), and LVX (≥0.2 µg mL−1) are successfully achieved at 1, 2, and 1 h, respectively. Thus, the use of DCTs offers promise to expand the range of drug molecules that can be delivered transdermally using MN patches. Novel, nonaqueous‐based, directly compressed tablets that are combined with hydrogel‐forming microneedle arrays are prepared and characterized. In vivo pharmacokinetic studies are conducted. Therapeutically relevant concentrations of amoxicillin (≥2 µg mL−1), levodopa (≥0.5 µg mL−1), and levofloxacin (≥0.2 µg mL−1) are successfully achieved at 1, 2, and 1 h, respectively.