Details

Autor(en) / Beteiligte

• Aeschbacher, Stefanie
• Beer, Jürg H.
• Bonati, Leo H.
• Sticherling, Christian
• Osswald, Stefan
• Conen, David
• Auberson, Chloé
• Blum, Steffen
• Doerpfeld, Simone
• Hämmerle, Peter
• Kühne, Michael
• Meyer-Zürn, Christine
• Meyre, Pascal
• Monsch, Andreas U.
• Müller, Christian
• Voellmin, Gian
• Zwimpfer, Leon
• Aujesky, Drahomir
• Fischer, Urs
• Jung, Simon
• Mattle, Heinrich
• Aubert, Carole Elodie
• Feller, Martin
• Loewe, Axel
• Moutzouri, Elisavet
• Schneider, Claudio
• Flückiger, Tanja
• Hellrigl, Sven
• Nuoffer, Alexandra
• Rakovic, Damiana
• Schwab, Nathalie
• Wenger, Rylana
• Rodondi, Nicolas
• Dillier, Roger
• Eberli, Franz
• Franzini, Christine
• Juchli, Isabel
• Liedtke, Claudia
• Obst, Thayze
• Schlomowitsch, Fiona
• Schneider, Xiaoye
• Studerus, Katrin
• Tynan, Noreen
• Weishaupt, Dominik
• Müller, Andreas
• Hischier, Denise
• Villinger, Jonas
• Laube, Eva
• Baumgartner, Philipp
• Filipovic, Mark
• Frick, Marcel
• Montrasio, Giulia
• Rutz, Franziska
• Beer, Jürg-Hans
• Auricchio, Angelo
• Camporini, Cristina
• Caputo, Maria Luce
• Regoli, Francois
• Moccetti, Tiziano
• Brenner, Roman
• Altmann, David
• Gemperle, Michaela
• Ammann, Peter
• Foucras, Sandrine
• Hayoz, Daniel
• Berte, Benjamin
• Meier, Sonja
• Ruckli-Kaeppeli, Andrea
• Russi, Ian
• Schmidt, Kai
• Young, Mabelle
• Zbinden, Melanie
• Kobza, Richard
• Frangi-Kultalahti, Jane
• Pin, Anica
• Vicari, Luisa
• Ehret, Georg
• Gallet, Hervé
• Perret, Patrick
• Tavel, Philippe
• Teres, Cheryl
• Shah, Dipen
• Méan, Marie
• Salzmann, Sandrine
• Grêt, Andrea
• Vitelli, Sandra
• Stephan, Frank-Peter
• Di Valentino, Marcello
• Witassek, Fabienne
• Schwenkglenks, Matthias
• Huber, Petra
• Coslovsky, Michael
• Benkert, Pascal
• Dutilh, Gilles
• Markovic, Milica
• Schmid, Ramun

Titel

Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Ist Teil von

• Heart rhythm, 2021-04, Vol.18 (4), p.512-519

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• The occurrence of congestive heart failure (CHF) hospitalization among patients with atrial fibrillation (AF) is a poor prognostic marker. The purpose of this study was to assess whether insulin-like growth factor-binding protein 7 (IGFBP-7), a marker of myocardial damage, identifies AF patients at high risk for this complication. We analyzed 2 prospective multicenter observational cohort studies that included 3691 AF patients. Levels of IGFBP-7 and N-terminal pro–brain natriuretic peptide (NT-proBNP) were measured from frozen plasma samples at baseline. The primary endpoint was hospitalization for CHF. Multivariable adjusted Cox regression analyses were constructed. Mean patient age was 69 ± 12 years, 1028 (28%) were female, and 879 (24%) had a history of CHF. The incidence per 1000 patient-years across increasing IGFBP-7 quartiles was 7, 10, 32, and 85. The corresponding multivariable adjusted hazard ratios (aHRs) (95% confidence interval [CI]) were 1.0, 1.05 (0.63–1.77), 2.38 (1.50–3.79), and 4.37 (2.72–7.04) (P for trend <.001). In a subgroup of 2812 patients without pre-existing CHF at baseline, the corresponding aHRs were 1.0, 0.90 (0.47–1.72), 1.69 (0.94–3.04), and 3.48 (1.94–6.24) (P for trend <.001). Patients with IGFBP-7 and NT-proBNP levels above the biomarker-specific median had a higher risk of incident CHF hospitalization (aHR 5.20; 3.35–8.09) compared to those with only 1 elevated marker (elevated IGFBP-7 aHR 2.17; 1.30–3.60); elevated NT-proBNP aHR 1.97; 1.17–3.33); or no elevated marker (reference). Higher plasma levels of IGFBP-7 were strongly and independently associated with CHF hospitalization in AF patients. The prognostic information provided by IGFBP-7 was additive to that of NT-proBNP. [Display omitted]