Details

Autor(en) / Beteiligte

• Chia, Noel
• Petersson, Fredrik

Titel

Adenoid cystic carcinoma with dedifferentiation/expansion of the luminal cell component and preserved biphasic morphology – Early high-grade transformation

Ist Teil von

• Annals of diagnostic pathology, 2021-02, Vol.50, p.151650-151650, Article 151650

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We present two patients (29 and 67 years) with histomorphologic and immunohistochemical evidence of early high-grade transformation of adenoid cystic carcinoma in the nasal cavity and floor of mouth, respectively. The component of early high-grade transformation was characterized by 1) selective expansion of the luminal (CK7+, c-kit+, p63-) cell component with severe cytologic atypia and significantly increased Ki-67 proliferation index, and 2) retained albeit attenuated abluminal (CK7-, c-kit-, p63+) cells, surrounding nests of high-grade luminal cells. •High-grade transformation of adenoid cystic carcinoma is a gradual process•Transformation entails luminal cell expansion, increased nuclear atypia and proliferation, and attrition of abluminal cells•Transition areas show high-grade carcinoma with preserved abluminal layer•Early high-grade transformation may have prognostic implications