Details

Autor(en) / Beteiligte

• Kong, Jung Hee
• Hu, Youmi
• Kong, Sun‐Young
• Lee, Se‐Na
• Eom, Hyeon‐Seok
• Lee, Hyewon
• Lee, Eunyoung
• Shim, Hyoeun

Titel

Analysis of laboratory parameters for optimal autologous peripheral blood stem cell collection from lymphoma and myeloma patients

Ist Teil von

• Journal of clinical apheresis, 2021-02, Vol.36 (1), p.135-142

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Background Peripheral blood stem cell (PBSC) collection is important for successful hematopoietic stem cell transplantation. This study aimed to investigate the laboratory parameters associated with the optimal timing of autologous PBSC collection from lymphoma and multiple myeloma patients. Methods We retrospectively evaluated data from 1105 PBSC apheresis procedures performed on 379 adult patients at the National Cancer Center between June 2005 and December 2019. Laboratory parameters, including cutoff values for the number of hematopoietic progenitor cells (HPCs) and circulating CD34+ cells, were analyzed to determine their association with CD34+ cell yield. Results The pre‐apheresis HPC and CD34+ cell count were statistically significant variables associated with harvested CD34+ cell in lymphoma and MM patients. The optimal cutoff values were 18 × 106/L for pre‐HPC count (66.8% sensitivity, 66.4% specificity) and 11/μL for pre‐CD34+ cell count (85.8% sensitivity, 87.2% specificity), to achieve CD34+ cell yields ≥ 1.0 × 106/kg for each apheresis procedure. Moreover, the optimal cutoff values were 23 × 106/L for pre‐HPC count (71.0% sensitivity, 69.0% specificity) and 18/μL for pre‐CD34+ cell count (87.5% sensitivity, 86.3% specificity) to achieve CD34+ cell yields ≥ 2.0 × 106/kg for each apheresis procedure. Conclusion HPC count is a potential surrogate marker for monitoring the starting time for PBSC collection. Applying cutoff values for the number of HPC and CD34+ cells may be clinically useful for optimizing the timing of PBSC collection.