Details

Autor(en) / Beteiligte

• Okada, Rieko
• Tsushita, Kazuyo
• Wakai, Kenji
• Kato, Kiminori
• Wada, Takashi
• Shinohara, Yukito

Titel

Healthy lifestyle reduces incidence of trace/positive proteinuria and rapid kidney function decline after 2 years: from the Japan Ningen Dock study

Ist Teil von

• Nephrology, dialysis, transplantation, 2021-06, Vol.36 (6), p.1039-1048

Ort / Verlag

Oxford University Press

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Background Lifestyle modification is recommended for subjects with trace proteinuria during health checkups. However, whether overall healthy lifestyle reduces the incidence of trace/positive proteinuria or rapid decline in estimated glomerular filtration rate (eGFR) is not clarified. Methods A total of 451 534 people (277 494 men and 174 040 women) ages 20–79 years with negative proteinuria were included. The number of three healthy lifestyle factors (LFs) was assessed: noncurrent smoking, healthy eating habits (late dinner, snacking and skipping breakfast <3 times/week) and body mass index <25. The incidence of trace (±) and positive (≥1+) proteinuria by the dipstick method and eGFR decline ≥20% over 2 years were compared with the number of healthy LFs. Results The incidence of trace/positive proteinuria and rapid eGFR decline decreased with an increasing number of healthy LFs as follows: odds ratios (ORs) for trace proteinuria, 0.91 [95% confidence interval (CI) 0.86–0.96], 0.82 (0.78–0.87) and 0.72 (0.68–0.77); ORs for positive proteinuria, 0.76 (95% CI 0.67–0.86), 0.56 (0.50–0.63) and 0.46 (0.40–0.53); and ORs for an eGFR decline ≥20%, 0.93 (95% CI 0.82–1.05), 0.90 (0.79–1.02) and 0.81 (0.70–0.93) for those with one, two and three healthy LFs compared with those with none of the three healthy LFs, respectively. Overall, subjects with a healthy lifestyle showed 28, 54 and 19% reduced risk of developing trace proteinuria, positive proteinuria and eGFR decline ≥20%, respectively, compared with those with an unhealthy lifestyle after 2 years. This association was similarly observed even among subjects without hypertension (HT) or diabetes mellitus (DM). Conclusions Subjects with an overall healthy lifestyle showed a lower incidence of trace/positive proteinuria by dipstick test and rapid eGFR decline over 2 years in a nationwide general population. Thus lifestyle modification should be recommended for subjects with trace proteinuria during health checkups, even for subjects without HT or DM. Graphical Abstract