Details

Autor(en) / Beteiligte

• Chen, Hong-Li
• Cui, Bo-Miao
• Kang, Ying-Zhu
• Wang, Li-Wei
• Wang, Jing-Nan
• Feng, Yun
• Zhang, Ping
• Lü, Die
• Chen, Jiao

Titel

Expression Level of Protein Kinase D in Oral Squamous Cell Carcinoma with Diverse Differentiation

Ist Teil von

• Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban, 2020-11, Vol.51 (6), p.755-759

Ort / Verlag

China

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• This study aimed to investigate the expression level of protein kinase D (PKD) in oral squamous cell carcinoma (OSCC) and its relationship with differentiation of OSCC. Sample was collected from 10 healthy control subjects and 40 OSCC confirmed by histopathological diagnosis, and the immunohistochemical staining was adopted to detect the expression of PKDs in OSCC tissues. The proportion of stained cell and staining intensity were evaluated to get a score, which used to analyze the difference among PKD1, PKD2 and PKD3 in various differentiation OSCC tissues. The correlations between the staining score of PKDs and differentiation of OSCC were further analyzed. PKD1 and PKD3 were high expression in OSCC tissues. There were statistical significance among the staining score of PKD1, PKD2 and PKD3 in various differentiation OSCC tissues ( <0.001). In addition, there was a significantly negative correlation between the staining score of PKD1 and PKD2 with the differentiation of OSCC ( =-0.574, -0.341, <0.001). In O