Environmental toxicology, 2021-04, Vol.36 (4), p.540-549
2021
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- Autor(en) / Beteiligte
- Titel
- Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway
- Ist Teil von
- Environmental toxicology, 2021-04, Vol.36 (4), p.540-549
- Ort / Verlag
- Hoboken, USA: John Wiley & Sons, Inc
- Erscheinungsjahr
- 2021
- Quelle
- Wiley Online Library All Journals
- Beschreibungen/Notizen
- Praeruptorin A (PA) is one of the active ingredients found in the dried root of Peucedanum praeruptorum Dunn, has been reported to possess anticancer effects against various types of cancer. However, the effect of PA on human hepatocellular carcinoma (HCC) remains uncleared. In this study, our results indicated that PA did not induce cytotoxicity or alter cell cycle distribution in human HCC cells (Huh‐7, SK‐Hep‐1, and PLC/PRF/5 cells). Instead, PA inhibited the migration and invasion of human HCC cells while downregulating the expression of matrix metalloproteinase‐1 (MMP1) and activating the extracellular signal‐regulated kinase (ERK) signaling pathways. Furthermore, blocking the ERK signaling pathway through siERK restored the expression of MMP1 and the invasive ability of PA‐treated HCC cells. In conclusion, our results demonstrate the antimetastatic activity of PA against human HCC cells, supporting its potential as a therapeutic agent of HCC treatments.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1520-4081eISSN: 1522-7278DOI: 10.1002/tox.23059Titel-ID: cdi_proquest_miscellaneous_2463606398
- Format
- –
- Schlagworte
- Anticancer properties, Antineoplastic Agents, Phytogenic - pharmacology, Cancer, Carcinoma, Hepatocellular - metabolism, Carcinoma, Hepatocellular - pathology, Cell Culture Techniques, Cell cycle, Cell Cycle - drug effects, Cell Line, Tumor, Cell Movement - drug effects, Cell Survival - drug effects, Cells, Chemical compounds, Coumarins - pharmacology, Cytotoxicity, Down-Regulation, ERK, Extracellular, Extracellular signal-regulated kinase, Extracellular Signal-Regulated MAP Kinases - metabolism, Hepatocellular carcinoma, hepatocellular carcinoma cells, Humans, Invasiveness, Kinases, Liver cancer, Liver Neoplasms - metabolism, Liver Neoplasms - pathology, MAP Kinase Signaling System - drug effects, Matrix metalloproteinase, Matrix Metalloproteinase 1 - metabolism, Matrix metalloproteinases, Metalloproteinase, Metastases, metastatsis, Mitogen-Activated Protein Kinase 3 - metabolism, MMP1, Neoplasm Invasiveness, Neoplasms, Pharmacology, praeruptorin A, Signal transduction, Signaling, Toxicity, Tumor Stem Cell Assay