Details

Autor(en) / Beteiligte

• Tanaka, Shin
• Luis Campo-Cañaveral de la Cruz, Jose
• Crowley Carrasco, Silvana
• Romero Román, Alejandra
• Hoyos Mejía, Lucas
• Manuel NaranjoGómez, Jose
• Córdoba Peláez, Mar
• Sánchez Calle, Álvaro
• Gil Barturen, Mariana
• Pérez Redondo, Marina
• García Fadul, Christian
• Varela de Ugarte, Andrés
• Gómez-de-Antonio, David

Titel

Effect on the donor lungs of using abdominal normothermic regional perfusion in controlled donation after circulatory death

Ist Teil von

• European journal of cardio-thoracic surgery, 2021-02, Vol.59 (2), p.359-366

Ort / Verlag

Germany: Oxford University Press

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract OBJECTIVES Controlled donation after circulatory death (cDCD) donors are becoming a common source of organs for transplantation globally. However, the graft survival rate of cDCD abdominal organs is inferior to that of organs from brain-dead donors. The rapid retrieval (RR) technique is used by most donor organ procurement teams. The abdominal normothermic regional perfusion (A-NRP) technique has been implemented to minimize warm ischaemic damage to the abdominal organs. However, there is limited information on the effect of A-NRP on the quality of the donor lungs. This study aimed to compare lung transplantation outcomes using lungs procured from cDCD donors using the A-NRP and abdominal RR techniques. METHODS A single-centre retrospective analysis of consecutive transplant recipients of cDCD lungs from June 2013 to December 2019 was performed. The recipients were divided into 2 cohorts according to the abdominal procurement technique used. The recipient and donor characteristics (age, sex, cause of brain injury, warm ischaemic time, diagnosis, lung allocation score and other factors), incidence of primary graft dysfunction and early survival were monitored. RESULTS Twenty-eight consecutive lung transplantation recipients were identified (median age 59 years; 61% male); 14 recipients received lungs using the A-NRP and 14 using abdominal RR for abdominal organ retrieval. There were no significant differences in the baseline characteristics, primary graft dysfunction (P = 0.70), hospital mortality (P = 1.0) and 1-year survival rate (P = 1.0) between the 2 groups. CONCLUSIONS No difference was observed in lung transplantation outcomes irrespective of the abdominal organ procurement technique used (A-NRP or abdominal RR). Lung transplantation (LTx) is an established therapy for end-stage lung disease in selected patients; however, it is limited by the shortage of donor organs [1].