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CACNA1C methylation: association with cortisol, perceived stress, rs1006737 and childhood trauma in males
Ist Teil von
Epigenomics, 2020-10, Vol.12 (19), p.1739-1749
Ort / Verlag
England
Erscheinungsjahr
2020
Link zum Volltext
Beschreibungen/Notizen
We investigated morning cortisol, stress, rs1006737 and childhood trauma relationship with
methylation.
Morning cortisol release, childhood trauma and perceived stress were collected and genotyping for rs1006737 conducted in 103 adult males. Genomic DNA extracted from saliva was bisulphite converted and using pyrosequencing methylation determined at 11 CpG sites within intron 3 of
.
A significant negative correlation between waking cortisol and overall mean methylation was found and a positive correlation between CpG5 methylation and perceived stress.
methylation levels may be related to cortisol release and stress perception. Future work should evaluate the influence of altered
methylation on stress reactivity to investigate this as a potential mechanism for mental health vulnerability.
Sprache
Englisch
Identifikatoren
ISSN: 1750-1911
eISSN: 1750-192X
DOI: 10.2217/epi-2020-0034
Titel-ID: cdi_proquest_miscellaneous_2459350178
Format
–
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