Details

Autor(en) / Beteiligte

• Rubbiani, Riccardo
• Wu, Wenyu
• Naik, Anu
• Larocca, Michele
• Schneider, Lukas
• Padrutt, Roxane
• Babu, Vipin
• König, Christiane
• Hinger, Doris
• Maake, Caroline
• Ferrari, Stefano
• Gasser, Gilles
• Spingler, Bernhard

Titel

Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling

Ist Teil von

• Chemical communications (Cambridge, England), 2020-11, Vol.56 (92), p.14373-14376

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67 Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS. Transplatin-modification of photosensitizers improves their phototoxic index without increasing their dark toxicity.