Details

Autor(en) / Beteiligte

• Csordás, Gábor
• Gábor, Erika
• Honti, Viktor

Titel

There and back again: The mechanisms of differentiation and transdifferentiation in Drosophila blood cells

Ist Teil von

• Developmental biology, 2021-01, Vol.469, p.135-143

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Transdifferentiation is a conversion of an already differentiated cell type into another cell type without the involvement of stem cells. This transition is well described in the case of vertebrate immune cells, as well as in Drosophila melanogaster, which therefore serves as a suitable model to study the process in detail. In the Drosophila larva, the latest single-cell sequencing methods enabled the clusterization of the phagocytic blood cells, the plasmatocytes, which are capable of transdifferentiation into encapsulating cells, the lamellocytes. Here we summarize the available data of the past years on the plasmatocyte-lamellocyte transition, and make an attempt to harmonize them with transcriptome-based blood cell clustering to better understand the underlying mechanisms of transdifferentiation in Drosophila, and in general. [Display omitted] •We summarize mechanisms which govern hemocyte differentiation in Drosophila.•We review new methods which allowed the re-evaluation of hemocyte classification.•The new advances in hemocyte transdifferentiation are discussed.