Details

Autor(en) / Beteiligte

• Zhang, Zi‐Jing
• Wen, Yu‐Hua
• Song, Jin
• Gong, Liu‐Zhu

Titel

Kinetic Resolution of Aziridines Enabled by N‐Heterocyclic Carbene/Copper Cooperative Catalysis: Carbene Dose‐Controlled Chemo‐Switchability

Ist Teil von

• Angewandte Chemie International Edition, 2021-02, Vol.60 (6), p.3268-3276

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Catalytic kinetic resolution (KR) and dynamic kinetic asymmetric transformation (DyKAT) are alternative and complementary avenues to access chiral stereoisomers of both starting materials and reaction products. The development of highly efficient chiral catalytic systems for kinetically controlled processes has therefore been one of the linchpins in asymmetric synthesis. N‐heterocyclic carbene (NHC)/copper cooperative catalysis has enabled highly efficient KR and DyKAT of racemic N‐tosylaziridines by [3+3] annulation with isatin‐derived enals, leading to highly enantioenriched N‐tosylaziridine derivatives (up to >99 % ee) and a large library of spirooxindole derivatives with high structural diversity and stereoselectivity (up to >95:5 d.r., >99 % ee). Mechanistic studies suggest that the NHC can bind reversibly to the copper catalyst without compromising its catalytic activity and regulate the catalytic activity of the copper complex to switch the chemoselection between KR and DyKAT. Highly efficient kinetic resolution and dynamic kinetic asymmetric transformation of racemic N‐tosylaziridines with isatin‐derived enals have been achieved by the cooperative catalysis of chiral N‐heterocyclic carbene (NHC) and copper complexes, leading to highly enantioenriched N‐tosylaziridines and spirooxindole derivatives with high structural diversity.