Details

Autor(en) / Beteiligte

• Zou, Zheng-Biao
• Zhang, Gang
• Li, Su-Mei
• He, Zhi-Hui
• Yan, Qing-Xiang
• Lin, Yu-Kun
• Xie, Chun-Lan
• Xia, Jin-Mei
• Luo, Zhu-Hua
• Luo, Lian-Zhong
• Yang, Xian-Wen

Titel

Asperochratides A–J, Ten new polyketides from the deep-sea-derived Aspergillus ochraceus

Ist Teil von

• Bioorganic chemistry, 2020-12, Vol.105, p.104349-104349, Article 104349

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• [Display omitted] •Ten new polyketides (1–10) were isolated the deep-sea-derived fungus Aspergillus ochraceus.•Their absolute configurations were determined by modified Mosher's method, ICD experiments, and ECD calculations.•All the new isolates possess aspyrone nucleus.•Plausible biosynthetic pathways for 1–11 and 16–18 was outlined. Ten new C9 polyketides (asperochratides A–J, 1–10) and 14 known miscellaneous compounds (11–24) were isolated from the deep-sea-derived fungus Aspergillus ochraceus. Structures of the new compounds were elucidated by extensive spectroscopic analyses, modified Mosher's method, Mo2(OAc)4 induced circular dichroism (ICD) experiments, and ECD calculations. Structurally, compounds 1–11 and 16–18 share the same polyketide origin of the skeleton and belong to aspyrone co-metabolites. All isolates were tested for cytotoxic, anti-food allergic, anti-H1N1 virus, anti-microbe, and anti-inflammatory activities in vitro. Results showed that compounds 5–8 and 13–17 exerted significant cytotoxic effects on BV-2 cell line, and compound 16 showed the potential of anti-inflammatory activities.