Details

Autor(en) / Beteiligte

• Tiraboschi, Juan M
• Rojas, Jhon
• Zetterberg, Henrik
• Blennow, Kaj
• Niubo, Jordi
• Gostner, Johanna
• Navarro-Alcaraz, Antonio
• Piatti, Camila
• Fuchs, Dietmar
• Gisslén, Magnus
• Rigo-Bonnin, Raul
• Martinez, Esteban
• Podzamczer, Daniel

Titel

No Changes in Human Immunodeficiency Virus (HIV) Suppression and Inflammatory Markers in Cerebrospinal Fluid in Patients Randomly Switched to Dolutegravir Plus Lamivudine (Spanish HIV/AIDS Research Network, PreEC/RIS 62)

Ist Teil von

• The Journal of infectious diseases, 2021-06, Vol.223 (11), p.1928-1933

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2021

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract A major concern of human immunodeficiency virus (HIV) dual therapy is a potentially lower efficacy in viral reservoirs, especially in the central nervous system (CNS). We evaluated HIV RNA, neuronal injury, and inflammatory biomarkers and dolutegravir (DTG) exposure in cerebrospinal fluid (CSF) in patients switching to DTG plus lamivudine (3TC). All participants maintained viral suppression in plasma and CSF at week 48. We observed no increase in CSF markers of inflammation or neuronal injury. Median (interquartile range) total and unbound DTG in CSF were 7.3 (5.9–8.4) and 1.7 (1.2–1.9) ng/mL, respectively. DTG+3TC may maintain viral control without changes in inflammatory/injury markers within the CNS reservoir. A major concern of human immunodeficiency virus dual therapy is a potential lower efficacy in viral reservoirs, especially in the central nervous system (CNS). Dolutegravir plus lamivudine may maintain viral control without changes in inflammatory/injury markers within the CNS reservoir.