Details

Autor(en) / Beteiligte

• Hoff, Birgit
• Plassmeier, Jens
• Blankschien, Matthew
• Letzel, Anne‐Catrin
• Kourtz, Lauralynn
• Schröder, Hartwig
• Koch, Walter
• Zelder, Oskar

Titel

Unlocking Nature's Biosynthetic Power—Metabolic Engineering for the Fermentative Production of Chemicals

Ist Teil von

• Angewandte Chemie (International ed.), 2021-02, Vol.60 (5), p.2258-2278

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Fermentation as a production method for chemicals is especially attractive, as it is based on cheap renewable raw materials and often exhibits advantages in terms of costs and sustainability. The tremendous development of technology in bioscience has resulted in an exponentially increasing knowledge about biological systems and has become the main driver for innovations in the field of metabolic engineering. Progress in recombinant DNA technology, genomics, and computational methods open new, cheaper, and faster ways to metabolically engineer microorganisms. Existing biosynthetic pathways for natural products, such as vitamins, organic acids, amino acids, or secondary metabolites, can be discovered and optimized efficiently, thereby enabling competitive commercial production processes. Novel biosynthetic routes can now be designed by the rearrangement of nature's unlimited number of enzymes and metabolic pathways in microbial strains. This expands the range of chemicals accessible by biotechnology and has yielded the first commercial products, while new fermentation technologies targeting novel active ingredients, commodity chemicals, and CO2‐fixation methods are on the horizon. Recent advances and future perspectives in microbial metabolic engineering are described in this Review, with a focus on selected commercially relevant examples. Existing biosynthetic pathways for natural products can now be easily discovered and optimized to enable competitive production processes. Moreover, nature's unlimited number of enzymes and metabolic pathways can now be rearranged to yield novel biosynthetic routes.