Details

Autor(en) / Beteiligte

• Caprifico, Anna E.
• Polycarpou, Elena
• Foot, Peter J. S.
• Calabrese, Gianpiero

Titel

Biomedical and Pharmacological Uses of Fluorescein Isothiocyanate Chitosan‐Based Nanocarriers

Ist Teil von

• Macromolecular bioscience, 2021-01, Vol.21 (1), p.e2000312-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Chitosan‐based nanocarriers (ChNCs) are considered suitable drug carriers due to their ability to encapsulate a variety of drugs and cross biological barriers to deliver the cargo to their target site. Fluorescein isothiocyanate‐labeled chitosan‐based NCs (FITC@ChNCs) are used extensively in biomedical and pharmacological applications. The main advantage of using FITC@ChNCs consists of the ability to track their fate both intra and extracellularly. This journey is strictly dependent on the physico‐chemical properties of the carrier and the cell types under investigation. Other applications make use of fluorescent ChNCs in cell labeling for the detection of disorders in vivo and controlling of living cells in situ. This review describes the use of FITC@ChNCs in the various applications with a focus on understanding their usefulness in labeled drug‐delivery systems. The present review highlights the usefulness of fluorescein isothiocyanate‐labeled chitosan nanocarriers (FITC@ChNCs) as a fluorescent tool employed in various biomedical and pharmacological applications. Some of these include investigations on the cellular uptake of FITC@ChNCs as drug delivery systems, in vivo cell labeling to detect disorders, and studies on the oral drug biodistribution.