Details

Autor(en) / Beteiligte

• Schuster, Iona S
• Andoniou, Christopher E

Titel

NKG7 – regulating endosomal pathways?

Ist Teil von

• Immunology and cell biology, 2020-11, Vol.98 (10), p.802-804

Ort / Verlag

United States: Blackwell Science Ltd

Erscheinungsjahr

2020

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Ng et al. have identified NKG7 as a regulator of inflammation in response to diverse immunological challenges. While NKG7 was required for the degranulation of cytotoxic cells, additional defects including reduced expansion and trafficking of CD8 T cells, and altered antigen presentation, were noted in NKG7‐deficient mice. The precise mechanism by which NKG7 mediates its effects has not been resolved but may involve regulation of endosomal vesicle trafficking.