Details

Autor(en) / Beteiligte

• Çelik, Malik
• Bayrak, Alkan
• Duramaz, Altuğ
• Başaran, Serdar Hakan
• Kızılkaya, Cemal
• Kural, Cemal
• Kural, Alev
• Sar, Mehmet
• Kaymakçı, Orkun

Titel

The effect of fibrin clot and C vitamin on the surgical treatment of Achilles tendon injury in the rat model

Ist Teil von

• Foot and ankle surgery, 2021-08, Vol.27 (6), p.681-687

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2021

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• •An experimental animal study on Achilles tendon tear.•Positive outcomes for Achilles tendon healing in histological, biochemical and biomechanical evaluation.•This procedure can be used in the clinic to speed up and strengthen the healing of Achilles tendon tears. This study aimed to determine the histological, biochemical, and biomechanical efficacy of fibrin clot and vitamin C in the healing of Achilles tendon ruptures (ATR) in a rat model. 52 adult Wistar-Albino rats (300–450 g) were used in the study. 12 rats were divided into four groups as Monitor (Group I), Control (Group II), Fibrin Clot (Group III), Fibrin Clot with vitamin C (Group IV). Four rats were used for fibrin clot preparation. Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF) were measured on the 3rd, 7th, 14th, and 21st days. Four rats were sacrificed on the 21st day from each group for histological evaluation. The rest of the rats were sacrificed at 42nd day, half for biomechanical and a half for histological evaluation. The 42nd-day HSS score of group IV was significantly lower than those of group I, group II and group III (p = 0.036, p = 0.019, and p = 0.036, respectively). Group IV showed a significantly higher Maximum force N value than those of group I, group II and group III (p = 0.034, p = 0.034 and, p = 0.025, respectively). The blood FGF and VEGF levels of group III and group IV on the 3rd, 7th, 14th, and 21st days were higher than those of group I and group II (p < 0.05). Fibrin clot and vitamin C produced a stronger tendon structure in terms of biomechanics while providing histological and biochemically better quality tendon healing in the surgical treatment of ATR. This model can be used to accelerate high-quality tendon healing after ATR. Level II, experimental study.