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Details

Autor(en) / Beteiligte
Titel
High-speed label-free ultraviolet photoacoustic microscopy for histology-like imaging of unprocessed biological tissues
Ist Teil von
  • Optics letters, 2020-10, Vol.45 (19), p.5401-5404
Ort / Verlag
Washington: Optical Society of America
Erscheinungsjahr
2020
Quelle
Optica Publishing Group Journals
Beschreibungen/Notizen
  • Ultraviolet photoacoustic microscopy (UV-PAM) has recently been demonstrated as a potential imaging tool for surgical margin analysis (SMA). UV-PAM does not require staining or micrometer-thick slicing, which is inevitable in conventional histological imaging. To promote UV-PAM as a practical intraoperative diagnostic tool, the imaging speed should be improved while preserving the high-resolution imaging capability and simplistic system design. In this Letter, we developed a galvanometer mirror-based UV-PAM (GM-UV-PAM) system for high-speed histology-like imaging. By using a UV laser with a high repetition rate (55 kHz) and a one-dimensional galvanometer mirror, our GM-UV-PAM system can generate subcellular images in less than 15 min for a typical brain biopsy ( 5 m m × 5 m m ), with a lateral resolution of ∼ 1.0 µ m . The images of mouse brain slices obtained by our GM-UV-PAM system show that it can provide histological information for SMA.
Sprache
Englisch
Identifikatoren
ISSN: 0146-9592
eISSN: 1539-4794
DOI: 10.1364/OL.401643
Titel-ID: cdi_proquest_miscellaneous_2448410048

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