Details

Autor(en) / Beteiligte

• Fedyanina, Olga S
• Filippova, Anna E
• Demina, Olga I
• Zhuliabina, Olga A
• Tikhomirov, Dmitry S
• Filatov, Alexander V
• Chebotareva, Tatiana A
• Kuznetsova, Sofya A

Titel

The Nature and Clinical Significance of Atypical Mononuclear Cells in Infectious Mononucleosis Caused by the Epstein-Barr Virus in Children

Ist Teil von

• The Journal of infectious diseases, 2021-05, Vol.223 (10), p.1699-1706

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Atypical mononuclear cells (AM) appear in significant numbers in peripheral blood of patients with Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). We investigated the number and lineage-specific clusters of differentiation (CD) expression of atypical mononuclear cells in 110 children with IM using the anti-CD antibody microarray for panning leukocytes by their surface markers prior to morphology examination. The AM population consisted primarily of CD8+ T cells with a small fraction (0%–2% of all lymphocytes) of CD19+ B lymphocytes. AM amount in children with mononucleosis caused by primary EBV infection was significantly higher than for IM caused by EBV reactivation or other viruses and constituted 1%–53% of all peripheral blood mononuclear cells compared to 0%–11% and 0%–8%, respectively. Children failing to recover from classic IM associated with primary EBV infection within 6 months had significantly lower percentage of CD8+ AM compared to patients with normal recovery rate. Using the anti-CD antibody microarray for panning leukocytes by their surface markers we show that atypical mononuclear cells in patients with infectious mononucleosis consist primarily of CD8+ T cells with a small fraction of CD19+ B lymphocytes.