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Trends and outcome of neoadjuvant treatment for rectal cancer: A retrospective analysis and critical assessment of a 10-year prospective national registry on behalf of the Spanish Rectal Cancer Project
European journal of surgical oncology, 2021-02, Vol.47 (2), p.276-284
2021
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Autor(en) / Beteiligte
Titel
Trends and outcome of neoadjuvant treatment for rectal cancer: A retrospective analysis and critical assessment of a 10-year prospective national registry on behalf of the Spanish Rectal Cancer Project
Ist Teil von
  • European journal of surgical oncology, 2021-02, Vol.47 (2), p.276-284
Ort / Verlag
England: Elsevier Ltd
Erscheinungsjahr
2021
Quelle
Access via ScienceDirect (Elsevier)
Beschreibungen/Notizen
  • Preoperative treatment and adequate surgery increase local control in rectal cancer. However, modalities and indications for neoadjuvant treatment may be controversial. Aim of this study was to assess the trends of preoperative treatment and outcomes in patients with rectal cancer included in the Rectal Cancer Registry of the Spanish Associations of Surgeons. This is a STROBE-compliant retrospective analysis of a prospective database. All patients operated on with curative intention included in the Rectal Cancer Registry were included. Analyses were performed to compare the use of neoadjuvant/adjuvant treatment in three timeframes: I)2006–2009; II)2010–2013; III)2014–2017. Survival analyses were run for 3-year survival in timeframes I-II. Out of 14,391 patients,8871 (61.6%) received neoadjuvant treatment. Long-course chemo/radiotherapy was the most used approach (79.9%), followed by short-course radiotherapy ± chemotherapy (7.6%). The use of neoadjuvant treatment for cancer of the upper third (15-11 cm) increased over time (31.5%vs 34.5%vs 38.6%,p = 0.0018). The complete regression rate slightly increased over time (15.6% vs 16% vs 18.5%; p = 0.0093); the proportion of patients with involved circumferential resection margins (CRM) went down from 8.2% to 7.3%and 5.5% (p = 0.0004). Neoadjuvant treatment significantly decreased positive CRM in lower third tumors (OR 0.71, 0.59–0.87, Cochrane-Mantel-Haenszel P = 0.0008). Most ypN0 patients also received adjuvant therapy. In MR-defined stage III patients, preoperative treatment was associated with significantly longer local-recurrence-free survival (p < 0.0001), and cancer-specific survival (p < 0.0001). The survival benefit was smaller in upper third cancers. There was an increasing trend and a potential overuse of neoadjuvant treatment in cancer of the upper rectum. Most ypN0 patients received postoperative treatment. Involvement of CRM in lower third tumors was reduced after neoadjuvant treatment. Stage III and MRcN + benefited the most.
Sprache
Englisch
Identifikatoren
ISSN: 0748-7983
eISSN: 1532-2157
DOI: 10.1016/j.ejso.2020.04.056
Titel-ID: cdi_proquest_miscellaneous_2444608943
Format
–
Schlagworte
Adult, Aged, Aged, 80 and over, Chemoradiotherapy, Adjuvant, Chemotherapy, Female, Follow-Up Studies, Forecasting, Humans, Male, Margins of Excision, Middle Aged, Neoadjuvant Therapy, Neoadjuvant treatment, Neoplasm Staging, Prognosis, Radiotherapy, Rectal cancer, Rectal Neoplasms - diagnosis, Rectal Neoplasms - epidemiology, Rectal Neoplasms - therapy, Registries, Retrospective Studies, Spain - epidemiology, Survival, Survival Rate - trends, T stage, TNM, Treatment Outcome, Young Adult

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