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Titel

Maternal and perinatal outcomes of pregnant women with SARS‐CoV‐2 infection

Ist Teil von

Ultrasound in obstetrics & gynecology, 2021-02, Vol.57 (2), p.232-241

Ort / Verlag

Chichester, UK: John Wiley & Sons, Ltd

Erscheinungsjahr

2021

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

ABSTRACT Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS‐CoV‐2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory‐confirmed SARS‐CoV‐2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS‐CoV‐2 infection was defined as a positive result on real‐time reverse‐transcription polymerase chain reaction (RT‐PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results In total, 388 women with a singleton pregnancy tested positive for SARS‐CoV‐2 on RT‐PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first‐trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251 (27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS‐CoV‐2 on RT‐PCR. Conclusions SARS‐CoV‐2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. © 2020 International Society of Ultrasound in Obstetrics and Gynecology

Sprache: Englisch
Identifikatoren: ISSN: 0960-7692
eISSN: 1469-0705
DOI: 10.1002/uog.23107
Titel-ID: cdi_proquest_miscellaneous_2442842926

Format: –
Schlagworte: Adult, Cohort Studies, coronavirus, COVID-19 - diagnosis, COVID-19 - mortality, COVID-19 - therapy, COVID-19 - virology, COVID‐19, Data analysis, Female, Gestation, Gynecology, Hospitalization - statistics & numerical data, Humans, Infant, Infant, Newborn, Infants, infection, Infections, Intensive Care Units - statistics & numerical data, Maternal Mortality, Mechanical ventilation, Morbidity, Mortality, Neonates, Obstetrics, Pandemics, Polymerase chain reaction, Pregnancy, Pregnancy Complications, Infectious - mortality, Pregnancy Complications, Infectious - therapy, Pregnancy Complications, Infectious - virology, Pregnancy Outcome, Premature birth, Respiration, Artificial - statistics & numerical data, Retrospective Studies, SARS-CoV-2 - genetics, SARS-CoV-2 - isolation & purification, SARS‐CoV‐2, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Ultrasound, Ventilation, Ventilators, Womens health

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Maternal and perinatal outcomes of pregnant women with SARS‐CoV‐2 infection

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