Details

Autor(en) / Beteiligte

• Cheng, Feifei
• Luk, Andrea O
• Tam, Claudia H T
• Fan, Baoqi
• Wu, Hongjiang
• Yang, Aimin
• Lau, Eric S H
• Ng, Alex C W
• Lim, Cadmon K P
• Lee, Heung Man
• Chow, Elaine
• Kong, Alice P
• Keech, Anthony C
• Joglekar, Mugdha V
• So, Wing Yee
• Jenkins, Alicia J
• Chan, Juliana C N
• Hardikar, Anandwardhan A
• Ma, Ronald C W

Titel

Shortened Relative Leukocyte Telomere Length Is Associated With Prevalent and Incident Cardiovascular Complications in Type 2 Diabetes: Analysis From the Hong Kong Diabetes Register

Ist Teil von

• Diabetes care, 2020-09, Vol.43 (9), p.2257-2265

Ort / Verlag

United States: American Diabetes Association

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Several studies support potential links between relative leukocyte telomere length (rLTL), a biomarker of biological aging, and type 2 diabetes. This study investigates relationships between rLTL and incident cardiovascular disease (CVD) in patients with type 2 diabetes. Consecutive Chinese patients with type 2 diabetes ( = 5,349) from the Hong Kong Diabetes Register for whom DNA obtained at baseline was stored and follow-up data were available were studied. rLTL was measured by using quantitative PCR. CVD was diagnosed on the basis of ICD-9 code. Mean follow-up was 13.4 years (SD 5.5 years). rLTL was correlated inversely with age, diabetes duration, blood pressure, HbA , and urine albumin-to-creatinine ratio (ACR), and positively with estimated glomerular filtration rate (eGFR) (all < 0.001). Subjects with CVD at baseline had a shorter rLTL (4.3 ± 1.2 ΔΔCt) than did subjects without CVD (4.6 ± 1.2 ΔΔCt) ( < 0.001). Of the 4,541 CVD-free subjects at baseline, the 1,140 who developed CVD during follow-up had a shorter rLTL (4.3 ± 1.2 ΔΔCt) than those who remained CVD-free after adjusting for age, sex, smoking, and albuminuria status (4.7 ± 1.2 ΔΔCt) ( < 0.001). In Cox regression models, shorter rLTL was associated with higher risk of incident CVD (for each unit decrease, hazard ratio 1.252 [95% CI 1.195-1.311], < 0.001), which remained significant after adjusting for age, sex, BMI, systolic blood pressure, LDL cholesterol, HbA , eGFR, and ACR (hazard ratio 1.141 [95% CI 1.084-1.200], < 0.001). rLTL is significantly shorter in patients with type 2 diabetes and CVD, is associated with cardiometabolic risk factors, and is independently associated with incident CVD. Telomere length may be a useful biomarker for CVD risk in patients with type 2 diabetes.