Details

Autor(en) / Beteiligte

• Dalton, C. Lucy
• Milinis, Kristijonas
• Houghton, David
• Ridley, Paul
• Davies, Katharine
• Williams, Richard
• Hamilton, David
• Wilkie, Mark D.
• Markey, Anne
• Clarke, Kim
• Lofthouse, Matthew
• Helliwell, Timothy R.
• Triantafyllou, Asterios
• Rodrigues, Jennifer
• Bheemireddy, Krishna
• Hanlon, Rebecca
• Wieshmann, Hulya
• Haridass, Anoop
• Brammer, Caroline
• Husband, David
• Shenoy, Aditya
• Loh, Christopher
• Roland, Nicholas J.
• Bekiroglu, Fazilet
• Tandon, Sankalap
• Lancaster, Jeffrey
• Jones, Terence M.

Titel

Transoral laser microsurgery and radiotherapy for oropharyngeal squamous cell carcinoma: Equitable survival and enhanced function compared with contemporary standards of care

Ist Teil von

• European journal of surgical oncology, 2020-11, Vol.46 (11), p.2042-2049

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We describe the 5-year oncological and functional outcomes of transoral laser microsurgery, neck dissection (TLM + ND) and adjuvant radiotherapy (PORT) used to treat patients with oropharyngeal carcinoma. The effectiveness of external carotid artery (ECA) ligation in reducing post-operative bleeding, and fibrin glue following ND in reducing wound drainage and length of hospital stay is reported. This retrospective case review of consecutive patients undergoing TLM between 2006 and 2017 used the Kaplan-Meier Estimator and Log-Rank Test for univariate, time-to-event analyses, and Cox-Proportionate Hazard modelling for multivariate analysis. 264 consecutive patients were included. Mean follow-up was 49.4 months. 219 (82.9%) patients received PORT. Five-year overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) rates were 74.9%, 73.7%, and 86.2%, respectively. Five-year locoregional control was 89.4%. 65.5% of cases were Human papillomavirus associated (HPV+), for whom OS, DFS and DSS was 85.6%, 84.7% and 92.7%, respectively, and demonstrated significantly higher OS (hazard ratio (HR) 0.28, CI 0.16–0.49, p < 0.0001), DFS (HR 0.28, CI 0.17–0.47, p < 0.0001) and DSS (HR 0.2, CI 0.09–0.44, <0.001). Post-operative oropharyngeal bleeding occurred in 23 patients (8.7%), of which 5 were major/severe, in patients without ECA ligation. Fibrin glue significantly reduced neck drain output (p < 0.001), and length of hospital stay (p < 0.001). One-year gastrostomy dependence rate was 2.3%. TLM + ND + PORT results in favourable 5-year survival and locoregional control rates, and low feeding tube dependency rates. ECA ligation and fibrin glue appear to reduce major post-operative haemorrhage, wound drainage and length of hospital stay.