Details

Autor(en) / Beteiligte

• Ni, Ying-Nan
• Kong, Liang
• Li, Xue-Tao
• Xiao, Hong-He
• Wu, Yu-Tong
• Liang, Xi-Cai
• Lin, Ying
• Li, Wan-Yi
• Deng, Yan
• Li, Yan
• Shi, Yue
• Cheng, Lan
• Li, Hong-Yan
• Ju, Rui-Jun
• Yang, Jing-Xian

Titel

Multifunctional osthole liposomes and brain targeting functionality with potential applications in a mouse model of Alzheimer's disease

Ist Teil von

• Journal of liposome research, 2021-07, Vol.31 (3), p.267-278

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2021

Beschreibungen/Notizen

• Osthole (Ost) is a coumarin compound and a potential drug for Alzheimer's disease (AD). However, the effectiveness of Ost is limited by solubility, bioavailability, and low permeability of the blood-brain barrier. In this study, we constructed Ost liposomes with modified CXCR4 on the surface (CXCR4-Ost-Lips), and investigated the intracellular distribution of liposomes in APP-SH-SY5Y cells. In addition, the neuroprotective effect of CXCR4-Ost-Lips was examined in vitro and in vivo. The results showed that CXCR4-Ost-Lips increased intracellular uptake by APP-SH-SY5Y cells and exerted a cytoprotective effect in vitro. The results of Ost brain distribution showed that CXCR4-Ost-Lips prolonged the cycle time of mice and increased the accumulation of Ost in the brain. In addition, CXCR4-Ost-Lips enhanced the effect of Ost in relieving AD-related pathologies. These results indicate that CXCR4-modified liposomes are a potential Ost carrier to treat AD.