Nutrition, metabolism, and cardiovascular diseases, 2020-10, Vol.30 (11), p.2085-2092
2020
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Immunoglobulins G modulate endothelial function and affect insulin sensitivity in humans
- Ist Teil von
- Nutrition, metabolism, and cardiovascular diseases, 2020-10, Vol.30 (11), p.2085-2092
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Data from animals suggest that immunoglobulins G (IgG) play a mechanistic role in atherosclerosis and diabetes through endothelial dysfunction and insulin resistance. Patients with common variable immunodeficiency (CVID), who have low circulating levels of IgG and are treated with intravenous polyclonal IgG (IVIgG), may provide an ideal model to clarify whether circulating IgG modulate endothelial function and affect insulin sensitivity in humans. We studied 24 patients with CVID and 17 matched healthy controls (HC). Endothelial function was evaluated as flow mediated dilation (FMD) of the brachial artery at baseline and 1, 7, 14, and 21 days after IVIgG infusion in the CVID patients. We measured also plasma glucose, insulin, and calculated the HOMA-IR index. We also investigated the role of human IgG on the production of Nitric Oxide (NO) in vitro in Human Coronary Artery Endothelial Cells (HCAEC). Compared to HC, FMD of CVID patients was significantly impaired at baseline (9.4 ± 0.9 and 7.6 ± 0.6% respectively, p < 0.05) but rose above normal levels 1 and 7 days after IVIgG infusion to return at baseline at 14 and 21 days. Serum insulin concentration and HOMA-IR index dropped by 50% in CVID patients after IVIgG (p < 0.002 vs. baseline). In vitro IgG stimulated NO production in HCAEC. Reduced IgG levels are associated with endothelial dysfunction and IVIgG stimulates endothelial function directly while improving insulin sensitivity. The current findings may suggest an anti-atherogenic role of human IgG. [Display omitted] •IgG can affect endothelial mediated nitric oxide bioavailability and play a role in the regulation of insulin sensitivity.•Circulating IgG might exert a tonic role and play an anti-atherogenic function in humans.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0939-4753eISSN: 1590-3729DOI: 10.1016/j.numecd.2020.07.001Titel-ID: cdi_proquest_miscellaneous_2435185971
- Format
- –
- Schlagworte
- Adolescent, Atherosclerosis, Biomarkers - blood, Blood Glucose - drug effects, Blood Glucose - metabolism, Brachial Artery - drug effects, Brachial Artery - metabolism, Brachial Artery - physiopathology, Case-Control Studies, Cells, Cultured, Common Variable Immunodeficiency - blood, Common Variable Immunodeficiency - drug therapy, Common Variable Immunodeficiency - physiopathology, Endothelial function, Endothelium, Vascular - drug effects, Endothelium, Vascular - metabolism, Endothelium, Vascular - physiopathology, Female, Flow mediated dilation, Humans, Immunoglobulin G - administration & dosage, Immunoglobulins, Immunoglobulins, Intravenous - administration & dosage, Infusions, Intravenous, Insulin - blood, Insulin Resistance, Male, Nitric Oxide - metabolism, Time Factors, Treatment Outcome, Vasodilation - drug effects, Young Adult