Details

Autor(en) / Beteiligte

• Keith, John M.
• Jones, William
• Pierce, Joan M.
• Seierstad, Mark
• Palmer, James A.
• Webb, Michael
• Karbarz, Mark
• Scott, Brian P.
• Wilson, Sandy J.
• Luo, Lin
• Wennerholm, Michelle
• Chang, Leon
• Rizzolio, Michele
• Rynberg, Raymond
• Chaplan, Sandra
• Guy Breitenbucher, J.

Titel

Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2020-10, Vol.30 (20), p.127463-127463, Article 127463

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] A series of mechanism-based heteroaryl urea fatty acid amide hydrolase (FAAH) inhibitors with fused bicyclic diamine cores is described. In contrast to compounds built around a piperazine core, most of the fused bicyclic diamine bearing analogs prepared exhibited greater potency against rFAAH than the human enzyme. Several compounds equipotent against both species were identified and profiled in vivo.