Details

Autor(en) / Beteiligte

• Greco, D.
• Santori, G.
• Brancato, G.
• Gossetti, F.
• Ipponi, P. L.
• Negro, P.
• Gianetta, E.
• Giovannini, S. C.
• Mascherini, M.
• Stabilini, C.

Titel

A new semiresorbable mesh for primary inguinal repair: a preliminary observational study on quality of life and safety

Ist Teil von

• Hernia : the journal of hernias and abdominal wall surgery, 2020-10, Vol.24 (5), p.1019-1031

Ort / Verlag

Paris: Springer Paris

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Background A currently unsolved problem of open inguinal hernia repair (IHR) is chronic postoperative inguinal pain (CPIP), which affects 10–12% of patients after IHR. In the present paper, we explored the results of a newly designed partially absorbable mesh made of polypropylene and polylactic acid (HybridMesh ® ) for open hernia repair and its impact on postoperative safety, efficacy, comfort and pain. Methods A prospective multicentric pilot trial was conducted in third-referral centers across Italy ( n  = 5). Inclusion criteria were unilateral primary inguinal hernia in patients of both genders and BMI < 30 kg/m 2 . All patients were submitted to elective Lichtenstein mesh hernia repair under local anesthesia with HybridMesh. Primary outcome measure was the evaluation of Carolina Comfort Scale and modifications at 2 years after surgery and its correlation with surgical variables; secondary outcomes were postoperative early and late morbidity, recurrence and postoperative early quality of life. Results Between 2015 and 2016, 125 (5 female) patients were operated, 2-year follow-up rate was 100%. The surgical site occurrence rate was 28% without the need of procedural interventions. Twenty-four months after surgery, no case of severe CPIP was recorded and altered global CCS score was present in 16 patients (13.0%). At univariate analysis, CCS score was negatively affected by fixation with sutures (OR 3.949; 95% CI 1.334–13.300), with no effect shown on multivariate analysis. Alterations in pain and movement limitations domains of CCS were observed in 9.7% of patients, at univariate analysis; they occurred more frequently when the mesh was sutured (OR 4.437; 95% CI 1.387–17.025) and in patients suffering from SSO (ecchymosis: OR 3.269; 95% CI 1.032–10.405); however, no effect was shown on multivariate analysis. Two recurrences (1.6%) were identified within the first postoperative year. Conclusions The results of this study support the safety, efficacy and good tolerability of HybridMesh as a device to treat primary unilateral inguinal hernia during open anterior approach. Further studies are needed to clarify its role in comparison to currently available devices at longer follow-ups.