Annals of neurology, 2020-11, Vol.88 (5), p.1023-1027
2020
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Details
- Autor(en) / Beteiligte
- Titel
- Effects of IgLON5 Antibodies on Neuronal Cytoskeleton: A Link between Autoimmunity and Neurodegeneration
- Ist Teil von
- Annals of neurology, 2020-11, Vol.88 (5), p.1023-1027
- Ort / Verlag
- Hoboken, USA: John Wiley & Sons, Inc
- Erscheinungsjahr
- 2020
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Anti‐IgLON5 disease is a neurological disorder characterized by autoantibodies against IgLON5 and pathological evidence of neuronal‐specific tau accumulation. Here, we report that patients' IgLON5 IgG, but not other cell‐surface antibodies, disrupt the cytoskeletal organization in cultured rat hippocampal neurons, resulting in dystrophic neurites and axonal swelling. Adsorption of IgLON5 IgG with HEK293 cells expressing IgLON5 abrogated the indicated cytoskeletal changes. These findings, along with an increase of levels of neurofilaments in patients' cerebrospinal fluid, suggest that IgLON5 IgG, unlike other cell‐surface antibodies, disrupts neuronal cytoskeleton maintenance, providing a link between autoimmunity and neurodegeneration. ANN NEUROL 2020;88:1023–1027
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0364-5134eISSN: 1531-8249DOI: 10.1002/ana.25857Titel-ID: cdi_proquest_miscellaneous_2430100486
- Format
- –
- Schlagworte
- Animals, Antibodies, Antibodies - pharmacology, Autoantibodies, Autoimmune diseases, Autoimmune Diseases - immunology, Autoimmunity, Axons, Axons - pathology, Cell Adhesion Molecules, Neuronal - immunology, Cell surface, Cells, Cultured, Cerebrospinal fluid, Cytoskeleton, Cytoskeleton - drug effects, HEK293 Cells, Hippocampus, Hippocampus - cytology, Humans, Immunoglobulin G, Immunoglobulin G - immunology, Neurites - pathology, Neurodegeneration, Neurodegenerative Diseases - immunology, Neurofilament Proteins - cerebrospinal fluid, Neurofilaments, Neurological diseases, Neurons - drug effects, Rats, Tau protein