Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127367-127367, Article 127367
2020
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Details
- Autor(en) / Beteiligte
- Titel
- Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127367-127367, Article 127367
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2020
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- [Display omitted] The synthesis and SAR development of a trisubstituted imidazole HDAC inhibitor is described. The compounds were synthesized with high diastereocontrol by leveraging Ellman sulfinyl imine chemistry. Structural elucidation provided insight into binding mode and supported design rational. Pharmacokinetic properties of lead compounds were determined.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2020.127367Titel-ID: cdi_proquest_miscellaneous_2430099692
- Format
- –
- Schlagworte
- HDAC, HIV, Latent reservoir, Medicinal chemistry, SAR analysis, X-ray structure