Details

Autor(en) / Beteiligte

• Kaliki, Swathi
• Palkonda, Vijay Anand Reddy

Titel

Second primary tumors in retinoblastoma survivors: a study of 7 Asian Indian patients

Ist Teil von

• International ophthalmology, 2020-12, Vol.40 (12), p.3303-3308

Ort / Verlag

Dordrecht: Springer Netherlands

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Purpose To assess the incidence, types, and outcomes of second primary tumors (SPT) in cases of retinoblastoma (RB) from a referral Tertiary eye care center Methods Retrospective chart review of 7 cases Results All 7 (100%) cases had bilateral RB at presentation. The mean age at diagnosis of RB was 16 months (median 7 months; range 5–72 months). Treatment of RB with intravenous chemotherapy was noted in 3 (43%) patients, 1 (14%) patient had received external beam radiotherapy (EBRT) to the orbit, 1 (14%) patient had received a combination of chemotherapy and orbital EBRT, while 4 (57%) patients had undergone primary enucleation of the worse eye and focal treatment of the better eye. The mean age at detection of SPT was 15 years (median 8 years; range 6–46 years). The mean time interval between diagnosis of RB and SPT was 13 years (median 7 years; range 1–41 years). The SPT’s included osteosarcoma of long bone ( n  = 2), eyelid sebaceous gland carcinoma ( n  = 2), ventricular ependymoma ( n  = 1), orbital neuroblastoma ( n  = 1), and acute lymphoblastic leukemia ( n  = 1). All patients received treatment for the SPT with either surgical excision ( n  = 2), intravenous chemotherapy ( n  = 1), or a combination of surgery/chemotherapy/radiotherapy (n = 4). Over a mean follow-up period of 8 years (median 8 years; range 4–11 years), one (14%) patient died, while other 6 (86%) patients are alive and well. Conclusion Though the incidence of SPT’s in cases of RB is rare, life-long follow-up is mandatory in at-risk patients.