Details

Autor(en) / Beteiligte

• He, Xiang-Kui
• Lu, Juan
• Zhang, Ai-Jun
• Zhang, Qing-Qing
• Xu, Guo-Yong
• Xuan, Jun

Titel

BI-OAc-Accelerated C3–H Alkylation of Quinoxalin-2(1H)‑ones under Visible-Light Irradiation

Ist Teil von

• Organic letters, 2020-08, Vol.22 (15), p.5984-5989

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An efficient, photoredox-catalyst-free radical alkylation of quinoxalin-2­(1H)-ones has been described. This reaction utilizes 4-alkyl-1,4-dihydropyridines (R-DHPs) as alkyl radical precursors and acetoxybenziodoxole (BI-OAc) as an electron acceptor to undergo single-electron transfer with photoexcited R-DHPs. The benign conditions allow for good compatibility in the scope of both quinoxalin-2­(1H)-ones and R-DHPs. The synthetic value of the protocol was also demonstrated by the successful functionalization of natural products and drug-based complex molecules