Details

Autor(en) / Beteiligte

• Oude Munnink, Bas B
• Nieuwenhuijse, David F
• Stein, Mart
• O'Toole, Áine
• Haverkate, Manon
• Mollers, Madelief
• Kamga, Sandra K
• Schapendonk, Claudia
• Pronk, Mark
• Lexmond, Pascal
• van der Linden, Anne
• Bestebroer, Theo
• Chestakova, Irina
• Overmars, Ronald J
• van Nieuwkoop, Stefan
• Molenkamp, Richard
• van der Eijk, Annemiek A
• GeurtsvanKessel, Corine
• Vennema, Harry
• Meijer, Adam
• Rambaut, Andrew
• van Dissel, Jaap
• Sikkema, Reina S
• Timen, Aura
• Koopmans, Marion

Titel

Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands

Ist Teil von

• Nature medicine, 2020-09, Vol.26 (9), p.1405-1410

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• In late December 2019, a cluster of cases of pneumonia of unknown etiology were reported linked to a market in Wuhan, China . The causative agent was identified as the species Severe acute respiratory syndrome-related coronavirus and was named SARS-CoV-2 (ref.  ). By 16 April the virus had spread to 185 different countries, infected over 2,000,000 people and resulted in over 130,000 deaths . In the Netherlands, the first case of SARS-CoV-2 was notified on 27 February. The outbreak started with several different introductory events from Italy, Austria, Germany and France followed by local amplification in, and later also outside, the south of the Netherlands. The combination of near to real-time whole-genome sequence analysis and epidemiology resulted in reliable assessments of the extent of SARS-CoV-2 transmission in the community, facilitating early decision-making to control local transmission of SARS-CoV-2 in the Netherlands. We demonstrate how these data were generated and analyzed, and how SARS-CoV-2 whole-genome sequencing, in combination with epidemiological data, was used to inform public health decision-making in the Netherlands.