Details

Autor(en) / Beteiligte

• Liu, Chao
• Chen, Xiao-Yan
• Yi, Mei-Hui
• Wu, Wen-Qi
• Ruan, Min
• Zhu, Xiao-Fan

Titel

Clinical features and prognosis of core binding factor acute myeloid leukemia in children

Ist Teil von

• Zhongguo dang dai er ke za zhi, 2020-07, Vol.22 (7), p.739-743

Erscheinungsjahr

2020

Quelle

Open access e-journals

Beschreibungen/Notizen

• OBJECTIVETo study the clinical features and prognosis of core binding factor acute myeloid leukemia (CBF-AML) in children.METHODSA retrospective analysis was performed from the chart review data of children who were newly diagnosed with CBF-AML in the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, from August 2009 to November 2015. According to the type of fusion gene, the children were divided into CBFB-MYH11 and AML1-ETO groups. Clinical features and prognosis were analyzed and compared between the two groups.RESULTSA total of 91 children with CBF-AML were enrolled in this study, among whom there were 74 (81%) in the AML1-ETO group and 17 (19%) in the CBFB-MYH11 group. Additional chromosomal abnormalities were observed in 38 children (42%), and deletion of sex chromosome was the most common abnormality and was observed in 28 children (31%). After the first course of induction treatment, the complete remission rate was 97% (88/91), the recurrence rate was 29% (26/91),