Details

Autor(en) / Beteiligte

• Riviere, Eugenia
• Rossi, Soledad P.
• Tavalieri, Yamil E.
• Muñoz de Toro, Mónica M.
• Ponzio, Roberto
• Puigdomenech, Elisa
• Levalle, Oscar
• Martinez, Gustavo
• Terradas, Claudio
• Calandra, Ricardo S.
• Matzkin, María E.
• Frungieri, Mónica B.

Titel

Melatonin daily oral supplementation attenuates inflammation and oxidative stress in testes of men with altered spermatogenesis of unknown aetiology

Ist Teil von

• Molecular and cellular endocrinology, 2020-09, Vol.515, p.110889-110889, Article 110889

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We have previously shown an inverse correlation between testicular melatonin concentration and inflammation/oxidative stress-related markers levels in infertile men showing unexplained azoospermia. Here, we evaluated the impact of melatonin oral supplementation (daily 3 mg dose used to treat sleep disorders) in the incidence of local inflammation, oxidative stress, and tubular wall fibrosis development in young and middle-aged infertile adult men. Compared with testes without histological alterations, gonads with morphological abnormalities showed lower melatonin concentration along with increased macrophage numbers, TBARS generation, and expression levels of inflammation-related markers and antioxidant enzymes, as well as tubular wall collagen fibers disorganization and thickening. Melatonin oral supplementation not only increased its own testicular levels but also decreased inflammation- and oxidative stress-related markers levels, and improved the tubular wall aspect. Overall, our work provides insights into the potential benefits of melatonin on the inflammatory and oxidative status in testes of patients suffering from unexplained infertility. •Inflammation/oxidative stress increase in testes of men with altered spermatogenesis.•Melatonin oral supplementation elevates its own testicular levels.•Testicular inflammation/oxidative stress lowered after melatonin oral intake.•Melatonin oral supplementation improves testicular tubular wall aspect.•Melatonin improves the overall inflammatory/oxidative testicular microenvironment.