Details

Autor(en) / Beteiligte

• Renesme, Laurent
• Dumas de la Roque, Eric
• Germain, Christine
• Chevrier, Agnès
• Rebola, Muriel
• Cramaregeas, Sophie
• Benard, Antoine
• Elleau, Christophe
• Tandonnet, Olivier

Titel

Nasal high‐frequency percussive ventilation vs nasal continuous positive airway pressure in newborn infants respiratory distress: A cross over clinical trial

Ist Teil von

• Pediatric pulmonology, 2020-10, Vol.55 (10), p.2617-2623

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Objective To determine if nasal high‐frequency percussive ventilation (nHFPV) to manage neonatal respiratory distress decreases the regional cerebral oxygen saturation (rScO2) compared to nasal continous positive airway pressure (nCPAP). Study Design A prospective, randomized, monocentric, open‐label, noninferiority crossover trial. Newborns of gestational age (GA) ≥ 33 weeks exhibiting persistent respiratory distress after 10 minutes of life were treated with nHFPV and nCPAP, in succession and in random order. The primary endpoint was the mean rScO2, as revealed by near‐infrared spectroscopy (NIRS). Results Forty‐nine newborns were randomized; the mean GA and birth weight was 36.4 ± 1.9 weeks and 2718 ± 497 g. The mean rScO2 difference during the last 5 minutes of each ventilation mode (nHFPV minus nCPAP) was –0.7 ± 5.4% (95% confidence interval (CI) –2.25; 0.95%). Conclusion In our study on newborns of GA ≥33 weeks treated for respiratory distress, cerebral oxygenation via nHFPV was not inferior to nCPAP.