Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Zur Ergebnisliste
Ergebnis 22 von 519
    Datensatz exportieren als...
  • BibTeX
The anti-inflammatory effect of ent-kaur-15-en-17-al-18-oic acid on lipopolysaccharide-stimulated RAW264.7 cells associated with NF-κB and P38/MAPK pathways
Journal of asian natural products research, 2021-06, Vol.23 (6), p.570-583
2021
Volltextzugriff (PDF)

Details

Autor(en) / Beteiligte
Titel
The anti-inflammatory effect of ent-kaur-15-en-17-al-18-oic acid on lipopolysaccharide-stimulated RAW264.7 cells associated with NF-κB and P38/MAPK pathways
Ist Teil von
  • Journal of asian natural products research, 2021-06, Vol.23 (6), p.570-583
Ort / Verlag
England: Taylor & Francis
Erscheinungsjahr
2021
Quelle
Taylor & Francis Journals Auto-Holdings Collection
Beschreibungen/Notizen
  • Ent-kaur-15-en-17-al-18-oic acid (LL-3) was demonstrated that it can inhibit LPS-induced nitric oxide (NO) production and macrophage migration, maintain homeostasis of oxidative stress, including increased mitochondrial membrane potential (MMP), decreased levels of reactive oxygen species (ROS) and malondialdehyde (MDA), and maintenance of superoxide dismutase (SOD) and glutathione (GSH) activities and inhibit oxidative stress-induced P38 and nuclear factor κB (NF-κB) pathways to decrease inducible nitric oxide synthase (iNOS), cyclooxygense-2 (COX-2), and tumour necrosis factor (TNF)-α mRNA expressions without marked cytotoxicity. These findings revealed that LL-3 could serve as a candidate lead compound for further studying anti-inflammatory therapies.
Sprache
Englisch
Identifikatoren
ISSN: 1028-6020
eISSN: 1477-2213
DOI: 10.1080/10286020.2020.1786371
Titel-ID: cdi_proquest_miscellaneous_2419422024
Format
–
Schlagworte
Animals, Anti-Inflammatory Agents - pharmacology, Cyclooxygenase 2 - genetics, Cyclooxygenase 2 - metabolism, Cyclooxygenase-2, Cytotoxicity, Diterpenes, Kaurane - pharmacology, Ent-kaur-15-en-17-al-18-oic acid, Glutathione, Homeostasis, Inflammation, Lead compounds, Leukocyte migration, Lipopolysaccharides, LPS, Macrophages, Malondialdehyde, MAP kinase, Membrane potential, Mice, migration, Mitochondria, Molecular Structure, mRNA, NF-kappa B - metabolism, NF-κB, NF-κB protein, Nitric oxide, Nitric Oxide - metabolism, Nitric Oxide Synthase Type II - genetics, Nitric Oxide Synthase Type II - metabolism, Nitric-oxide synthase, Oxidative stress, p38 Mitogen-Activated Protein Kinases, RAW 264.7 Cells, Reactive oxygen species, Signal Transduction, Superoxide dismutase, Toxicity, Tumor necrosis factor-TNF, Tumor necrosis factor-α, Tumors

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX