Details

Autor(en) / Beteiligte

• Lenouvel, Daniel
• González‐Moles, Miguel Ángel
• Ruiz‐Ávila, Isabel
• Chamorro‐Santos, Clara
• González‐Ruiz, Lucía
• González‐Ruiz, Isabel
• Ramos‐García, Pablo

Titel

Clinicopathological and prognostic significance of PD‐L1 in oral cancer: A preliminary retrospective immunohistochemistry study

Ist Teil von

• Oral diseases, 2021-03, Vol.27 (2), p.173-182

Ort / Verlag

Denmark: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To evaluate the relation between PD‐L1 expression in oral cavity squamous cell carcinomas and clinicopathological features as well as survival outcomes. Methods A retrospective immunohistochemical study was carried out on 55 archived tumours from 55 patients. Tumours were stained for PD‐L1 and scored by the proportion of tumour cells with positive membranous staining. PD‐L1 scores were compared to the patient's clinicopathological characteristics for any significant associations. Kaplan–Meier curves were constructed for PD‐L1 positive and negative tumours to investigate any advantage to survival. Results Positive PD‐L1 staining was found in 58% of tumours and was significantly more likely in non‐smokers, non‐drinkers and in tongue squamous cell carcinomas. Increased PD‐L1 was also associated with increased lymphocyte infiltration as well as PD‐L1 staining in lymphocytes and the epithelium adjacent to tumour invasion. No survival benefit was seen from PD‐L1 expression in tumour cells. Conclusions PD‐L1 expression is more common in non‐smokers and non‐drinkers, and its presence in the adjacent non‐tumour epithelium suggests it may be involved in early oncogenesis.