Details

Autor(en) / Beteiligte

• Long, Quan-Xin
• Tang, Xiao-Jun
• Shi, Qiu-Lin
• Li, Qin
• Deng, Hai-Jun
• Yuan, Jun
• Hu, Jie-Li
• Xu, Wei
• Zhang, Yong
• Lv, Fa-Jin
• Su, Kun
• Zhang, Fan
• Gong, Jiang
• Wu, Bo
• Liu, Xia-Mao
• Li, Jin-Jing
• Qiu, Jing-Fu
• Chen, Juan
• Huang, Ai-Long

Titel

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

Ist Teil von

• Nature medicine, 2020-08, Vol.26 (8), p.1200-1204

Ort / Verlag

New York: Nature Publishing Group US

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT–PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. Asymptomatic individuals were admitted to the government-designated Wanzhou People’s Hospital for centralized isolation in accordance with policy 1 . The median duration of viral shedding in the asymptomatic group was 19 d (interquartile range (IQR), 15–26 d). The asymptomatic group had a significantly longer duration of viral shedding than the symptomatic group (log-rank P  = 0.028). The virus-specific IgG levels in the asymptomatic group (median S/CO, 3.4; IQR, 1.6–10.7) were significantly lower ( P  = 0.005) relative to the symptomatic group (median S/CO, 20.5; IQR, 5.8–38.2) in the acute phase. Of asymptomatic individuals, 93.3% (28/30) and 81.1% (30/37) had reduction in IgG and neutralizing antibody levels, respectively, during the early convalescent phase, as compared to 96.8% (30/31) and 62.2% (23/37) of symptomatic patients. Forty percent of asymptomatic individuals became seronegative and 12.9% of the symptomatic group became negative for IgG in the early convalescent phase. In addition, asymptomatic individuals exhibited lower levels of 18 pro- and anti-inflammatory cytokines. These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys. A cohort of asymptomatic patients infected with SARS-CoV-2 had significantly lower levels of virus-specific IgG antibodies compared to a cohort of age- and sex-matched symptomatic infected patients.