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Substantia Nigra Volumetry with 3-T MRI in De Novo and Advanced Parkinson Disease
Radiology, 2020-08, Vol.296 (2), p.401-410
Vitali, Paolo
Pan, Marina I
Palesi, Fulvia
Germani, Giancarlo
Faggioli, Arianna
Anzalone, Nicoletta
Francaviglia, Pietro
Minafra, Brigida
Zangaglia, Roberta
Pacchetti, Claudio
Gandini Wheeler-Kingshott, Claudia A M
2020
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Vitali, Paolo
Pan, Marina I
Palesi, Fulvia
Germani, Giancarlo
Faggioli, Arianna
Anzalone, Nicoletta
Francaviglia, Pietro
Minafra, Brigida
Zangaglia, Roberta
Pacchetti, Claudio
Gandini Wheeler-Kingshott, Claudia A M
Titel
Substantia Nigra Volumetry with 3-T MRI in De Novo and Advanced Parkinson Disease
Ist Teil von
Radiology, 2020-08, Vol.296 (2), p.401-410
Ort / Verlag
United States
Erscheinungsjahr
2020
Quelle
MEDLINE
Beschreibungen/Notizen
Background Magnetization transfer-prepared T1-weighted MRI can depict a hyperintense subregion of the substantia nigra involved in the degeneration process of Parkinson disease. Purpose To evaluate quantitative measurement of substantia nigra volume by using MRI to support clinical diagnosis and staging of Parkinson disease. Materials and Methods In this prospective study, a high-spatial-resolution magnetization transfer-prepared T1-weighted volumetric sequence was performed with a 3-T MRI machine between January 2014 and October 2015 for participants with de novo Parkinson disease, advanced Parkinson disease, and healthy control participants. A reproducible semiautomatic quantification analysis method that entailed mesencephalic intensity as an internal reference was used for hyperintense substantia nigra volumetry normalized to intracranial volume. A general linear model with age and sex as covariates was used to compare the three groups. Results Eighty participants were evaluated: 20 healthy control participants (mean age ± standard deviation, 56 years ± 11; 11 women), 29 participants with de novo Parkinson disease (64 years ± 10; 19 men), and 31 participants with advanced Parkinson disease (60 years ± 9; 16 women). Volumetric measurement of hyperintense substantia nigra from magnetization transfer-prepared T1-weighted MRI helped differentiate healthy control participants from participants with advanced Parkinson disease (mean difference for ipsilateral side, 64 mm ± 14, < .001; mean difference for contralateral side, 109 mm ± 14, < .001) and helped distinguish healthy control participants from participants with de novo Parkinson disease (mean difference for ipsilateral side, 45 mm ± 15, < .01; mean difference for contralateral side, 66 mm ± 15, < .001) and participants with de novo Parkinson disease from those with advanced Parkinson disease (mean difference for ipsilateral side, 20 mm ± 13, = .40; mean difference for contralateral side, 43 mm ± 13, = .004). Conclusion Magnetization transfer-prepared T1-weighted MRI volumetry of the substantia nigra helped differentiate the stages of Parkinson disease. © RSNA, 2020
Sprache
Englisch
Identifikatoren
ISSN: 0033-8419
eISSN: 1527-1315
DOI: 10.1148/radiol.2020191235
Titel-ID: cdi_proquest_miscellaneous_2414406157
Format
–
Schlagworte
Aged
,
Female
,
Humans
,
Magnetic Resonance Imaging - methods
,
Male
,
Middle Aged
,
Parkinson Disease - diagnostic imaging
,
Parkinson Disease - pathology
,
Prospective Studies
,
Substantia Nigra - anatomy & histology
,
Substantia Nigra - diagnostic imaging
,
Substantia Nigra - pathology
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