Details

Autor(en) / Beteiligte

• Abdallah, Maha M.
• Fernández, Naiara
• Matias, Ana A.
• Bronze, Maria do Rosário

Titel

Hyaluronic acid and Chondroitin sulfate from marine and terrestrial sources: Extraction and purification methods

Ist Teil von

• Carbohydrate polymers, 2020-09, Vol.243, p.116441-116441, Article 116441

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• •Glycosaminoglycans are extracted from marine and terrestrial by-products.•Various methods are developed to isolate hyaluronic acid and chondroitin sulfate.•The extraction and purification techniques are compared to assess the efficiency.•The yield and purity depend on the technique and by-products used. Hyaluronic acid (HA) and chondroitin sulfate (CS) are valuable bioactive polysaccharides that have been highly used in biomedical and pharmaceutical applications. Extensive research was done to ensure their efficient extraction from marine and terrestrial by-products at a high yield and purity, using specific techniques to isolate and purify them. In general, the cartilage is the most common source for CS, while the vitreous humor is main used source of HA. The developed methods were based in general on tissue hydrolysis, removal of proteins and purification of the target biopolymers. They differ in the extraction conditions, enzymes and/or solvents used and the purification technique. This leads to specific purity, molecular weight and sulfation pattern of the isolated HA and CS. This review focuses on the analysis and comparison of different extraction and purification methods developed to isolate these valuable biopolymers from marine and terrestrial animal by-products.