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A 5‐Year Longitudinal Clinical and Magnetic Resonance Imaging Study in Spinocerebellar Ataxia Type 3
Movement disorders, 2020-09, Vol.35 (9), p.1679-1684
Piccinin, Camila Callegari
Rezende, Thiago Junqueira Ribeiro
Paiva, Jean Levi Ribeiro
Moysés, Pedro Cury
Martinez, Alberto Rolim Muro
Cendes, Fernando
França, Marcondes Cavalcante
2020
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Piccinin, Camila Callegari
Rezende, Thiago Junqueira Ribeiro
Paiva, Jean Levi Ribeiro
Moysés, Pedro Cury
Martinez, Alberto Rolim Muro
Cendes, Fernando
França, Marcondes Cavalcante
Titel
A 5‐Year Longitudinal Clinical and Magnetic Resonance Imaging Study in Spinocerebellar Ataxia Type 3
Ist Teil von
Movement disorders, 2020-09, Vol.35 (9), p.1679-1684
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2020
Quelle
MEDLINE
Beschreibungen/Notizen
Background The natural history of neurodegeneration in spinocerebellar ataxia type 3/Machado Joseph disease is still unclear. Here, we built a long‐term longitudinal clinical and neuroimaging study to address this point. Methods Twenty‐three patients with spinocerebellar ataxia type 3/Machado Joseph disease and 22 healthy controls underwent 3T MRI twice 5.0 years apart. T1 and diffusion tensor imaging sequences were obtained. We used T1 multiatlas, diffusion tensor imaging multiatlas, SpineSeg, and CERES‐SUIT for cerebral gray and white matter, spinal cord and cerebellar analyses, respectively. Clinical severity was assessed with scale for assessment and rating of ataxia. Analysis of covariance evaluated longitudinal between‐group changes. Effect sizes were calculated for each significant result. Results Progressive volumetric abnormalities were most evident in the cerebellum (Lobule X and Crus II; effect size, 2.0), followed by the basal ganglia (effect size, 0.7). The cerebellar peduncles had the largest white‐matter diffusivity changes (effect size, 1.29). Scale for assessment and rating of ataxia–related effect size was 0.82. We failed to identify progressive spinal cord abnormalities. Conclusions Longitudinal changes in spinocerebellar ataxia type 3/Machado Joseph disease are more evident in the cerebellum and connections, followed by the basal ganglia. © 2020 International Parkinson and Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.28113
Titel-ID: cdi_proquest_miscellaneous_2411105256
Format
–
Schlagworte
Ataxia
,
Basal ganglia
,
Cerebellum
,
Diffusion Tensor Imaging
,
effect size
,
Humans
,
Machado Joseph disease
,
Machado-Joseph Disease - diagnostic imaging
,
Machado-Joseph Disease - genetics
,
Magnetic Resonance Imaging
,
Movement disorders
,
Neurodegeneration
,
Neuroimaging
,
Spinal cord
,
spinocerebellar ataxia type 3
,
Spinocerebellar Ataxias - diagnostic imaging
,
Spinocerebellar Ataxias - genetics
,
Substantia alba
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