Details

Autor(en) / Beteiligte

• Levesque, Eric
• Lim, Chetana
• Feray, Cyrille
• Salloum, Chady
• Quere, Anne‐Laure
• Robin, Benoit
• Merle, Jean‐Claude
• Esposito, Francesco
• Duvoux, Christophe
• Cherqui, Daniel
• Habibi, Anoosha
• Galacteros, Frédéric
• Bartolucci, Pablo
• Azoulay, Daniel

Titel

Liver transplantation in patients with sickle cell disease: possible but challenging—a cohort study

Ist Teil von

• Transplant international, 2020-10, Vol.33 (10), p.1220-1229

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2020

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Summary The liver is frequently affected in patients with sickle cell disease (SCD), but few reports have described liver transplantation (LT) in patients with SCD. We present a thorough analysis of the largest single‐center series of LT in patients with SCD and the first systematic review. There were 21 patients with a median age of 37.6 years. LT was performed for acute liver failure related to the sickling process (57%) or electively for end‐stage liver disease (43%). Prior to LT, 13 patients (62%) were in the intensive care unit and required mechanical ventilation (33%), vasopressor therapy (24%), renal replacement therapy (10%), or molecular adsorbent recirculating system therapy (19%). Post‐LT morbidity and mortality were 95% and 33%, respectively. Patient survival at 1 and 5 years were 58.3% and 41.7%, respectively, in the urgent group and 88.9% and 77.8%, respectively, in the elective group. A total of 22 transplant patients with SCD are described in 20 articles in the literature. The 1‐ and 5‐year patient survival rates for the 18 evaluable patients were 75% and 65%, respectively. LT improves survival in patients with SCD and acute liver failure or end‐stage liver disease but is associated with high morbidity during the early postoperative course.