Details

Autor(en) / Beteiligte

• Eaton, Patrick
• Lewis, Thomas
• Kellett‐Wright, Johanna
• Flatt, Aidan
• Urasa, Sarah
• Howlett, William
• Dekker, Marieke
• Kisoli, Aloyce
• Rogathe, Jane
• Thornton, Jessica
• McCartney, Judith
• Yarwood, Vanessa
• Irwin, Charlotte
• Mukaetova‐Ladinska, Elizabeta B.
• Akinyemi, Rufus
• Gray, William K.
• Walker, Richard W.
• Dotchin, Catherine L.
• Makupa, Philip C.
• Quaker, Andrew‐Leon S.
• Paddick, Stella‐Maria

Titel

Risk factors for symptomatic HIV‐associated neurocognitive disorder in adults aged 50 and over attending a HIV clinic in Tanzania

Ist Teil von

• International journal of geriatric psychiatry, 2020-10, Vol.35 (10), p.1198-1208

Ort / Verlag

Chichester, UK: John Wiley & Sons, Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Objectives HIV‐associated neurocognitive disorder (HAND), although prevalent, remains a poorly researched cause of morbidity particularly in sub‐Saharan Africa (SSA). We aimed to explore the risk factors for HAND in people aged 50 and over under regular follow‐up at a government HIV clinic in Tanzania. Methods HIV‐positive adults aged 50 years and over were approached for recruitment at a routine HIV clinic appointment over a 4‐month period. A diagnostic assessment for HAND was implemented, including a full medical/neurological assessment and a collateral history from a relative. We investigated potential risk factors using a structured questionnaire and by examination of clinic records. Results Of the cohort (n = 253), 183 (72.3%) were female and the median age was 57 years. Fifty‐five individuals (21.7%) met the criteria for symptomatic HAND. Participants were at a greater risk of having symptomatic HAND if they lived alone [odds ratio (OR) = 2.566, P = .015], were illiterate (OR 3.171, P = .003) or older at the time of HIV diagnosis (OR = 1.057, P = .015). Age was correlated with symptomatic HAND in univariate, but not multivariate analysis. Conclusions In this setting, HIV‐specific factors, such as nadir CD4 count, were not related to symptomatic HAND. The “legacy theory” of early central nervous system damage prior to initiation of anti‐retroviral therapy initiation may contribute, only in part, to a multifactorial aetiology of HAND in older people. Social isolation and illiteracy were associated with symptomatic HAND, suggesting greater cognitive reserve might be protective.